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| Week 1 | Sunday, September 09 | Kansas City | at | Houston | 1:00 PM |
| Week 2 | Sunday, September 16 | Houston | at | Carolina | 1:00 PM |
| Week 3 | Sunday, September 23 | Indianapolis | at | Houston | 1:00 PM |
| Week 4 | Sunday, September 30 | Houston | at | Atlanta | 1:00 PM |
| Week 5 | Sunday, October 07 | Miami | at | Houston | 1:00 PM |
| Week 6 | Sunday, October 14 | Houston | at | Jacksonville | 1:00 PM |
| Week 7 | Sunday, October 21 | Tennessee | at | Houston | 1:00 PM |
| Week 8 | Sunday, October 28 | Houston | at | San Diego | 4:05 PM |
| Week 9 | Sunday, November 04 | Houston | at | Oakland | 4:15 PM |
| Week 11 | Sunday, November 18 | New Orleans | at | Houston | 1:00 PM |
| Week 12 | Sunday, November 25 | Houston | at | Cleveland | 1:00 PM |
| Week 13 | Sunday, December 02 | Houston | at | Tennessee | 1:00 PM |
| Week 14 | Sunday, December 09 | Tampa Bay | at | Houston | 1:00 PM |
| Week 15 | Thursday, December 13 | Denver | at | Houston | 8:15 PM |
| Week 16 | Sunday, December 23 | Houston | at | Indianapolis | 1:00 PM |
| Week 17 | Sunday, December 30 | Jacksonville | at | Houston | 1:00 PM |
Game Time Weather Forecast at Houston Texans  |
