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| Week 1 | Sunday, September 09 | Denver | at | Buffalo | 1:00 PM |
| Week 2 | Sunday, September 16 | Buffalo | at | Pittsburgh | 1:00 PM |
| Week 3 | Sunday, September 23 | Buffalo | at | New England | 1:00 PM |
| Week 4 | Sunday, September 30 | NY Jets | at | Buffalo | 1:00 PM |
| Week 5 | Monday, October 08 | Dallas | at | Buffalo | 8:30 PM |
| Week 7 | Sunday, October 21 | Baltimore | at | Buffalo | 1:00 PM |
| Week 8 | Sunday, October 28 | Buffalo | at | NY Jets | 4:05 PM |
| Week 9 | Sunday, November 04 | Cincinnati | at | Buffalo | 1:00 PM |
| Week 10 | Sunday, November 11 | Buffalo | at | Miami | 1:00 PM |
| Week 11 | Sunday, November 18 | New England | at | Buffalo | 1:00 PM |
| Week 12 | Sunday, November 25 | Buffalo | at | Jacksonville | 1:00 PM |
| Week 13 | Sunday, December 02 | Buffalo | at | Washington | 1:00 PM |
| Week 14 | Sunday, December 09 | Miami | at | Buffalo | 1:00 PM |
| Week 15 | Sunday, December 16 | Buffalo | at | Cleveland | 1:00 PM |
| Week 16 | Sunday, December 23 | NY Giants | at | Buffalo | 1:00 PM |
| Week 17 | Sunday, December 30 | Buffalo | at | Philadelphia | 1:00 PM |
Game Time Weather Forecast at Philadelphia Eagles  |
